Vilanterol trifenatate
CAS No. 503070-58-4
Vilanterol trifenatate ( GW642444 (trifenatate) )
产品货号. M21986 CAS No. 503070-58-4
Vilanterol trifenatate is a long-acting agonist of β2-adrenoceptor (β2-AR) with inherent 24-hour activity(β2-AR, β1-AR and β3-AR pEC50s of 10.37, 6.98 and 7.36, respectively).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1843 | 有现货 |
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10MG | ¥3077 | 有现货 |
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25MG | ¥4550 | 有现货 |
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50MG | ¥6971 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Vilanterol trifenatate
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Vilanterol trifenatate is a long-acting agonist of β2-adrenoceptor (β2-AR) with inherent 24-hour activity(β2-AR, β1-AR and β3-AR pEC50s of 10.37, 6.98 and 7.36, respectively).
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产品描述Vilanterol trifenatate is a long-acting agonist of β2-adrenoceptor (β2-AR) with inherent 24-hour activity(β2-AR, β1-AR and β3-AR pEC50s of 10.37, 6.98 and 7.36, respectively)The preclinical pharmacological profile of vilanterol using radioligand binding and cAMP studies in recombinant assays as well as human and guinea pig tissue systems to characterize β(2)-AR binding and functional properties.?Vilanterol displayed a subnanomolar affinity for the β(2)-AR that was comparable with that of salmeterol but higher than olodaterol, formoterol, and indacaterol.?In cAMP functional activity studies, vilanterol demonstrated similar selectivity as salmeterol for β(2)- over β(1)-AR and β(3)-AR, but a significantly improved selectivity profile than formoterol and indacaterol.?Vilanterol also showed a level of intrinsic efficacy that was comparable to indacaterol but significantly greater than that of salmeterol.
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同义词GW642444 (trifenatate)
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通路Angiogenesis
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靶点Adrenergic Receptor
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受体β2-adrenoceptor;β1-adrenoceptor;β3-adrenoceptor
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研究领域——
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适应症——
化学信息
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CAS Number503070-58-4
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分子量774.77
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分子式C44H49Cl2NO7
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纯度>98% (HPLC)
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溶解度DMSO:100 mg/mL (129.07 mM; Need ultrasonic)
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SMILESOC(=O)C(c1ccccc1)(c1ccccc1)c1ccccc1.OCc1cc(ccc1O)[C@@H](O)CNCCCCCCOCCOCc1c(Cl)cccc1Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册
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